Karl leads Development at Dewpoint Therapeutics. He is a seasoned physician-scientist with over 20 years of experience in clinical drug development, specializing in oncology and hematology. He has authored or co-authored more than 30 peer-reviewed publications. Karl has held key positions at several organizations, including his role as Senior Vice President of Clinical Research and Early Development at Zai Laboratory. There, he oversaw the Early Development Oncology, Clinical Pharmacology, and Translational Medicine groups.
Karl also worked at Sanofi, where he served as the Global Head of Development Strategy and Science. In this role, he led development initiatives for various business opportunities and managed several academic strategic alliances. He also served as the Global Head of Early Development Oncology, where he built and led a team responsible for strategizing and executing the oncology pipeline for hematologic and solid tumor malignancies, guiding projects from research to clinical proof of concept. Notably, Karl contributed to the early development of the anti-CD38 monoclonal antibody, isatuximab (Sarclisa).
Earlier in his career, Karl was with Merck Research Laboratories as the Early Development Leader for several oncology pipeline molecules.
Karl earned his medical degree from the Perelman School of Medicine at the University of Pennsylvania. He completed his Internal Medicine training at the Osler Medical Service of Johns Hopkins Hospital and his Oncology/Hematology training at Beth Israel Deaconess Medical Center.
Outside of work, Karl enjoys cooking and spending time with his wife, three kids, and two dogs.